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Principal Investigator

Principal Investigator

We welcome young and enthusiastic scientists to our laboratory!

Tetsuro IZUMI
Job title: Professor
Degree: M.D., Ph.D.

We aim to study basic biological phenomena that are deeply related with the pathogenesis of diabetes, obesity, and associated diseases. To study these subjects from a molecular level to a whole body level, we are using multidisciplinary techniques of morphology, biochemistry, molecular biology, and genetics. One of our major research areas is regulated exocytosis, which is instrumental for cell-cell communication in multicellular organisms. We are particularly focusing on insulin granule exocytosis in pancreatic beta cells, the impairment of which instantly leads to hyperglycemia. Another subject is fat accumulation in adipocytes, which is of course central to the development of obesity. Furthermore, we have recently begun to study immune cells, the disorder of which is involved in insulin resistance and chronic inflammation associated with metabolic diseases.

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OFFICE ADDRESS

Laboratory of Molecular Endocrinology and Metabolism,Department of Molecular Medicine,
Institute for Molecular and Cellular Regulation, Gunma University
3-39-15 Showa-machi, Maebashi, Gunma, Japan 371-8512
Fax: +81-27-220-8860 / E-mail: tizumi@gunma-u.ac.jp

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EDUCATION / DEGREES

1976 – 1978 Premedical Course, University of Tokyo (Komaba, Tokyo, Japan)
1978 – 1982 Faculty of Medicine, University of Tokyo (Hongo, Tokyo, Japan)
1982 Doctor of Medicine (M.D.)
1989 Doctor of Medical Science (Ph.D.)

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POSITIONS/EMPLOYMENT

1982 – 1983 Resident, Department of Internal Medicine, University of Tokyo Hospital
1983 – 1984 Resident, Department of Internal Medicine, Mitsui Memorial Hospital
1984 – 1985 Physician and Research Fellow (Dr. Masato Kasuga), Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
1985 – 1986 Research Fellow (Dr. Yasuo Akanuma), Institute of Diabetes Care and Research, Asahi Life Foundation
1986 – 1989 Physician and Research Fellow (Dr. Masato Kasuga), Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
1989 – 1992 Assistant Professor, Third Department of Internal Medicine,　Faculty of Medicine, University of Tokyo
1990 Postdoctoral Fellow (Dr. James L. Maller), Department of Pharmacology, University of Colorado School of Medicine, CO, USA
1990 – 1994 Research Associate (Dr. James L. Maller), Howard Hughes Medical Institute, Department of Pharmacology, University of Colorado School of Medicine, CO, USA
1994 – 2000 Associate Professor, Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University
2000 – Professor, Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University

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RESEARCH AREAS

1984 – 1990 Insulin action and signal transduction of growth factors
1990 – 1994 Cell cycle
1994 – Regulated exocytosis (especially insulin secretion) Genetics and pathogenesis of diabetes and obesity in rodent models

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OFFICE ADDRESS

American Diabetes Association (USA)
European Association for the Study of Diabetes (Europe)
Japan Diabetes Society, Councilor
Japan Endocrine Society, Councilor
Japan Society of Experimental Diabetes and Obesity, Auditor, Councilor
Japanese Society of Molecular Medicine, Councilor
Japan Society for Cell Biology, Councilor
Japanese Biochemical Society
Molecular Biology Society of Japan
Japanese Society of Internal Medicine

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SELECTED PUBLICATIONS

  1. Yogosawa S, Mizutani S, Ogawa Y, and Izumi T (2013). Activin receptor-like kinase 7 suppresses lipolysis to accumulate fat in obesity through downregulation of peroxisome proliferator-activated receptor γ and C/EBPα. Diabetes, 62, 115-123.
  2. Kasai K, Fujita T, Gomi H, and Izumi T (2008). Docking is not a prerequisite but a temporal constraint for fusion of secretory granules. Traffic, 9, 1191-1203.
  3. Gomi H, Mizutani S, Kasai K, Itohara S, and Izumi T (2005). Granuphilin molecularly docks insulin granules to the fusion machinery. J. Cell. Biol., 171, 99-109.
  4. Kasai K, Ohara-Imaizumi M, Takahashi N, Mizutani S, Zhao S, Kikuta T, Kasai H, Nagamatsu S, Gomi H, and Izumi T (2005). Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. J. Clin. Invest., 115, 388-396.
  5. Yi Z, Yokota H, Torii S, Aoki T, Hosaka M, Zhao S, Takata K, Takeuchi T, and Izumi T (2002). The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules. Mol. Cell. Biol., 22, 1858-1867.
  6. Wang J, Takeuchi T, Yokota H, and Izumi T (1999). Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells. J. Biol. Chem., 274, 28542-28548.
  7. Hirayama I, Yi Z, Izumi S, Arai I, Suzuki W, Nagamachi Y, Kuwano H, Takeuchi T, and Izumi T (1999). Genetic analysis of obese diabetes in the TSOD mouse. Diabetes, 48, 1183-1191.
  8. Wang J, Takeuchi T, Tanaka S, Kubo S-K, Kayo T, Lu D, Takata K, Koizumi A, and Izumi T (1999). A mutation in the insulin 2 gene induces diabetes with severe pancreatic b-cell dysfunction in the Mody mouse. J. Clin. Invest., 103, 27-37.
  9. Izumi T, Walker DH, and Maller JL (1992). Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity. Mol. Biol. Cell, 3, 927-939.
  10. Izumi T, White MF, Kadowaki T, Takaku F, Akanuma Y, and Kasuga M (1987). Insulin-like growth factor I rapidly stimulates tyrosine phosphorylation of a Mr 185,000 protein in intact cells. J. Biol. Chem., 262, 1282-1287.

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