文字サイズ

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Publications

Publications

2017

  • Fan F, Matsunaga K, Wang H, Ishizaki R, Kobayashi E, Kiyonari H, Mukumoto Y, Okunishi K, Izumi T (2017). Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa. Elife 2017 Jul 4;6. pii: e26174. [PubMed]
  • Matsunaga K, Taoka M, Isobe T, Izumi T (2017). Rab2a and Rab27a cooperatively regulate the transition from granule maturation to exocytosis through the dual effector Noc2. J Cell Sci 2017 130: 541-550.[J. Cell Sci.]

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2016

  • Mizuno K, Fujita T, Gomi H, and Izumi T (2016). Granuphilin exclusively mediates functional granule docking to the plasma membrane. Sci. Rep., 6, 23909.[PubMed]
  • Yamaoka M, Ando T, Terabayashi T, Okamoto M, Takei M, Nishioka T, Kaibuchi K, Matsunaga K, Ishizaki R, Izumi T, Niki I, Ishizaki T, Kimura T (2016). PI3K regulates endocytosis after insulin secretion by mediating signaling crosstalk between Arf6 and Rab27a. J Cell Sci, 129, 637-649. [PubMed]

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2015

  • Shimada-Sugawara M, Sakai E, Okamoto K, Fukuda M, Izumi T, Yoshida N, and Tsukuba T (2015). Rab27A regulates transport of cell surface receptors modulating multinucleation and lysosome-related organelles in osteoclasts. Sci Rep, 5, 9620. [PubMed]

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2013

  • Fujimoto Y, Nakagawa Y, Satoh A, Okuda K, Shingyouchi A, Naka A, Matsuzaka T, Iwasaki H, Kobayashi K, Yahagi N, Shimada M, Yatoh S, Suzuki H, Yogosawa S, Izumi T, Sone H, Urayama O, Yamada N, Shimano H (2013). TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis. Endocrinology, 154, 3577-3588. [PubMed]
  • Yogosawa S and Izumi T (2013). Roles of activin receptor-like kinase 7 signaling and its target, peroxisome proliferator-activated receptor γ, in lean and obese adipocytes. Adipocyte, 2, 246-250. [PubMed]
  • Wang H, Ishizaki R, Xu J, Kasai K, Kobayashi E, Gomi H, Izumi T (2013). The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane. Mol. Biol. Cell, 24, 319-330. [PubMed]
  • Yogosawa S, Mizutani S, Ogawa Y, and Izumi T (2013). Activin receptor-like kinase 7 suppresses lipolysis to accumulate fat in obesity through downregulation of peroxisome proliferator-activated receptor γ and C/EBPα. Diabetes, 62, 115-123. [PubMed]

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2012

  • Izumi T (2012). Adipose cell and lipid turnovers in obesity and insulin resistance. Diabetol. Int. 3, 184-186. [SpringerLink]
  • Xu X, Coats JK, Yang CF, Wang A, Ahmed OM, Alvarado M, Izumi T, and Shah NM (2012). Modular genetic control of sexually dimorphic behaviors. Cell, 148, 596-607. [PubMed]

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2011

  • Wang H, Ishizaki R, Kobayashi E, Fujiwara T, Akagawa K, and Izumi T (2011). Loss of granuphilin and loss of syntaxin-1a cause differential effects on insulin granule docking and fusion. J. Biol. Chem. 286, 32244-32250. [PubMed]
  • Mizuno K, Ramalho JS, and Izumi T (2011). Exophilin8 transiently clusters insulin granules at the actin-rich cell cortex prior to exocytosis. Mol. Biol. Cell, 22, 1716-1726. [PubMed]
  • Izumi T (2011). Heterogeneous modes of insulin granule exocytosis: molecular determinants. Front. Biosci., 16, 360-367. [PubMed]

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2010

  • Matsunaga K, Morita E, Saitoh T, Akira S, Ktistakis NT, Izumi T, Noda T, and Yoshimori T (2010). Autophagy requires endoplasmic reticulum targeting of the Pl3-kinase complex via Atg14L. J. Cell Biol., 190, 511-521. [PubMed]
  • Maeda-Mamiya R, Noiri E, Isobe H, Nakanishi W, Okamoto K, Doi K, Sugaya T, Izumi T, Homma T, and Nakamura E (2010). In vivo gene delivery by cationic tetraamino fullerene. Proc. Natl. Acad. Sci. USA, 107, 5339-5344. [PubMed]

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2009

  • Guo X, Tu L, Gumper I, Plesken H, Novak EK, Chintala S, Swank RT, Pastores G, Torres P, Izumi T, Sun T-T, Sabatini DD, and Kreibich G (2009). Involvement of Vps33a in the fusion of uroplakin-degrading multivesicular bodies with lysosomes. Traffic, 10, 1350-1361. [PubMed]

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2008

  • Kasai K, Fujita T, Gomi H, and Izumi T (2008). Docking is not a prerequisite but a temporal constraint for fusion of secretory granules. Traffic, 9, 1191-1203. [PubMed]
  • Chavas LMG, Ihara K, Kawasaki M, Torii S, Uejima T, Kato R, Izumi T, and Wakatsuki S (2008).Elucidation of Rab27 recruitement by its effector: structure of Rab27a bound to Exophilin4/Slp2-a. Structure, 16, 1468-1477[PubMed]
  • Chavas LMG, Ihara K, Kawasaki M, Kato R, Izumi T,and Wakatsuki S (2008). Purification, crystallization and preliminary X-ray crystallographic analysis of Rab27a GTPase in complex with exophilin4/Slp2-a effector. Acta Crystallogr. Sect. F. Biol. Cryst. Commun., 64, 599-601[PubMed]
  • Kasai K, Suga K, Izumi T, and Akagawa K (2008). Syntaxin 8 has two functionally distinct di-leucine-based motifs. Cell. Mol. Biol. Lett., 13, 144-154. [PubMed]

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2007

  • Yu M, Kasai K, Nagashima K, Torii S, Yokota-Hashimoto H, Okamoto K, Takeuchi T, Gomi H, and Izumi T (2007). Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain. Mol. Biol. Cell, 18, 688-696. [PubMed]
  • Gomi H, Mori K, Itohara S, and Izumi T (2007). Rab27b is expressed in a wide range of exocytic cells and involved in the delivery of secretory granules near the plasma membrane. Mol. Biol. Cell, 18, 4377-4386. [PubMed]
  • Hosaka M, Watanabe T, Yamauchi Y, Sakai Y, Suda M, Mizutani S, Takeuchi T, Isobe T, and Izumi T (2007). A subset of p23 localized on secretory granules in the pancreatic β-cells. J. Histochem. Cytochem., 55, 235-245. [PubMed]
  • Chavas LMG, Torii S, Kamikubo H, Kawasaki M, Ihara K, Kato R, Kataoka M, Izumi T and Wakatsuki S (2007). Structure of the small GTPase Rab27b shows an unexpected swapped dimer. Acta. Crystallogr. D Biol. Crystallogr., 63, 769-779. [PubMed]
  • Izumi T, Kasai K, and Gomi H (2007). Secretory vesicle docking to the plasma membrane: molecular mechanism and functional significance. Diabetes. Obes. Metab., 9 (Suppl. 2), 109-117. [PubMed]
  • Izumi T. (2007) Physiological roles of Rab27 effectors in regulated exocytosis. Endocr. J., 54, 649-657. [PubMed]

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2006

  • Kato T, Shimano H, Yamamoto T, Yokoo T, Endo Y, Ihikawa M, Matsuzaka T, Nakagawa Y, KumadakiS, Yahagi N, Takahashi A, Sone H, Suzuki H, Toyoshima H, Hasty AH, Takahashi S, Gomi H, Izumi T, and Yamada N (2006). Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice. Cell Metab., 4, 143-154. [PubMed]
  • Mizutani S, Gomi H, Hirayama I, and Izumi T (2006). Chromosome 2 locus Nidd5 has a potent effect on adiposity in the TSOD mouse. Mamm. Genome, 17, 375-384. [PubMed]

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2005

  • Torii S, Saito N, Kawano A, Zhao S, Izumi T, and Takeuchi T (2005).Cytoplasmic Transport Signal is Involved in Phogrin Targeting and Localization to Secretory Granules. Traffic, 6, 1213-1224. [PubMed]
  • Gomi H, Mizutani S, Kasai K, Itohara S, and Izumi T (2005). Granuphilin molecularly docks insulin granules to the fusion machinery. J. Cell. Biol., 171, 99-109. [PubMed]
  • Izumi T, Gomi H, and Torii S (2005). Functional analysis of Rab27a effector granuphilin in insulin exocytosis. Methods Enzymol., 403, 216-229. [PubMed]
  • Kasai K, Ohara-Imaizumi M, Takahashi N, Mizutani S, Zhao S, Kikuta T, Kasai H, Nagamatsu S, Gomi H, and Izumi T (2005). Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. J. Clin. Invest., 115, 388-396. [PubMed]

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2004

  • Chen X, Li C, Izumi T, Ernst SA, Andrews PC, and Williams JA (2004). Rab27b localizes to zymogen granules and regulates pancreatic acinar exocytosis. Biochem. Biophys. Res. Commun., 323, 1157-1162. [PubMed]
  • Torii S, Takeuchi T, Nagamatsu S, and Izumi T (2004). Rab27 effector granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a. J. Biol. Chem., 279, 22532-22538. [PubMed]
  • Fujisawa T, Kamimura H, Hosaka M, Torii S, Izumi T, Kuwano H, and Takeuchi T (2004). Functional localization of proprotein-convertase furin and its substrate TGFβ in EGF receptor-expressing gastric chief cells. Growth Factors, 22, 51-59. [PubMed]
  • Hosaka M, Suda M, Sakai Y, Izumi T, Watanabe T, and Takeuchi T (2004). Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A. J. Biol. Chem., 279, 3627-3634. [PubMed]

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2003

  • Izumi T, Gomi H, Kasai K, Mizutani S, and Torii S (2003). The roles of Rab27 and its effectors in the regulated secretory pathways. Cell Struct. Funct., 28, 465-474. [PubMed]
  • Chen Y, Guo X, Deng F-M, Liang F-X, Sun W, Ren M, Izumi T, Sabatini DD, Sun T-T, and Kreibich G (2003). Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes. Proc. Natl. Acad. Sci. USA, 24, 14012-14017. [PubMed]
  • Zhang B, Hosaka M, Sawada Y, Torii S, Mizutani S, Ogata M, Izumi T, and Takeuchi T (2003). Parathyroid hormone-related protein induces insulin expression through activation of MAP kinase-specific phosphatase-1 that dephosphorylates c-Jun NH2-terminal kinase in pancreatic β-cells. Diabetes, 52, 2720-2730. [PubMed]
  • Yaguchi M, Nagashima K, Izumi T, and Okamoto K (2003). Neurological study of C57BL/6 Akita mouse, type 2 diabetic model: enhanced expression of αB-crystallin in oligodendrocytes. Neuropathology, 23, 44-50. [PubMed]
  • Izumi T, Yokota-Hashimoto H, Zhao S, Wang J, Halban PA, and Takeuchi T(2003). Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse. Diabetes, 52, 409-416. [PubMed]

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2002

  • Torii S, Zhao S, Yi Z, Takeuchi T, and Izumi T (2002). Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a. Mol. Cell. Biol., 22, 5518-5526. [PubMed]
  • Nagashima K, Torii S, Yi Z, Igarashi M, Okamoto K, Takeuchi T, and Izumi T (2002). Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions. FEBS Lett., 517, 233-238. [PubMed]
  • Zhao S, Torii S, Yokota-Hashimoto H, Takeuchi T, and Izumi T (2002). Involvement of Rab27b in the regulated secretion of pituitary hormones. Endocrinology, 143, 1817-1824. [PubMed]
  • Yi Z, Yokota H, Torii S, Aoki T, Hosaka M, Zhao S, Takata K, Takeuchi T, and Izumi T (2002). The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules. Mol. Cell. Biol., 22, 1858-1867. [PubMed]

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2001

  • Sawada Y, Zhang B, Okajima F, Izumi T, and Takeuchi T (2001). PTHrP increases pancreatic β-cell-specific function in well-differentiated cells. Mol. Cell. Endocrinol.,182, 265-275. [PubMed]
  • Negishi M, Lu D, Zhang YQ, Sawada Y, Sasaki T, Kayo T, Ando J, Izumi T, Kurabayashi M, Kojima I, Masuda H, and Takeuchi T (2001). Upregulatory expression of furin and transforming growth factor-β by fluid shear stress in vascular endothelial cells. Arterioscler. Thromb. Vasc. Biol., 21, 785-790. [PubMed]

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2000

  • Sawada Y, Kameya T, Aizawa T, Izumi T, and Takeuchi T (2000). Proprotein-processing endoprotease furin and its substrate parathyroid hormone-related protein are coexpressed in insulinoma cells. Endocr. Pathol., 11, 31-39. [PubMed]

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1999

  • Wang J, Takeuchi T, Yokota H, and Izumi T (1999). Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells. J. Biol. Chem., 274, 28542-28548. [PubMed]
  • Hirayama I, Tamemoto H, Yokota H, Kubo S-K, Wang J, Kuwano H, Nagamachi Y, Takeuchi T, and Izumi T (1999). Insulin receptor-related receptor is expressed in pancreatic β-cells and stimulates tyrosine phosphorylation of insulin receptor substrates-1 and -2. Diabetes, 48, 1237-1244. [PubMed]
  • Hirayama I, Yi Z, Izumi S, Arai I, Suzuki W, Nagamachi Y, Kuwano H, Takeuchi T, and Izumi T (1999). Genetic analysis of obese diabetes in the TSOD mouse. Diabetes, 48, 1183-1191. [PubMed]
  • Wang J, Takeuchi T, Tanaka S, Kubo S-K, Kayo T, Lu D, Takata K, Koizumi A, and Izumi T (1999). A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse. J. Clin. Invest., 103, 27-37. [PubMed]

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