群馬大学生体調節研究所 遺伝生化学分野 泉研究室

I studied the roles of immune cells in the immune-mediated and lung diseases mainly using mouse models at the University of Tokyo (2002-2008). Then, I moved to University of Michigan (Dr. Marc Peters-Golden’s laboratory), and there, I studied the mechanism by which prostaglandin E2 suppresses functions of macrophages and lung fibroblasts (2008-2012). Now, since I joined this Lab in April 2012, I am enthusiastically studying the roles of regulated secretory machinery in the immune system and in the lung.

1. Okunishi K, Sisson TH, Huang SK, Hogaboam CM, Simon RH, Peters-Golden M (2011). Plasmin overcomes resistance to prostaglandin E2 in fibrotic lung fibroblasts by reorganizing protein kinase a signalling. J. Biol. Chem., 286, 32231-32243.
2. Bauman KA*, Wettlaufer SH*, Okunishi K*, Vannella KM, Stoolman JS, Huang SK, Courey AJ, White ES, Hogaboam CM, Simon RH, Toews GB, Sisson TH, Moore BB, Peters-Golden M (2010). The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice. J. Clin. Invest., 120, 1950-1960.　 *, equally contributed.
3. Okunishi K, Dohi M, Fujio K, Nakagome K, Tabata Y, Okasora T, Seki M, Shibuya M, Imamura M, Harada H, Tanaka R, Yamamoto K (2007). Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice. J. Immunol., 179, 5504-5513.
4. Okunishi K, Dohi M, Nakagome K, Tanaka R, Mizuno S, Matsumoto K, Miyazaki J, Nakamura T, Yamamoto K (2005). A novel role of hepatocyte growth factor as an immune regulator through suppressing dendritic cell function. J. Immunol., 175, 4745-4753.
5. Okunishi K, Dohi M, Nakagome K, Tanaka R, Yamamoto K (2004). A novel role of cysteinyl leukotrienes to promote dendritic cell activation in the antigen-induced immune responses in the lung. J. Immunol., 173, 6393-6402.