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We previously demonstrated that granuphilin, an effector of the small GTPase Rab27a, mediates the stable attachment (docking) of insulin granules to the plasma membrane. However, recent total internal reflection fluorescence (TIRF) microscopic recordings in living cells have demonstrated that granules without prior stable docking to the plasma membrane can efficiently undergo exocytosis, alth…
We recently discovered a novel signaling pathway involving activin receptor-like kinase 7 (ALK7), one of the type I transforming growth factor-β receptors. ALK7 inhibits CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ) specifically in differentiated adipocytes. Despite the inhibition of these master regulators of adipogenesis, it surprisingly …